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Molecular Dynamics Analyses of Prion Protein Structures - 9789811342479
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Item specifics
- Condition
- Book Title
- Molecular Dynamics Analyses of Prion Protein Structures
- ISBN
- 9789811342479
- Publication Year
- 2018
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Molecular Dynamics Analyses of Prion Protein Structures: the Resistance to Prion Diseases Down under
- Item Height
- 235mm
- Publisher
- Springer Verlag, Singapore
- Item Width
- 155mm
- Subject
- Chemistry
- Item Weight
- 837g
- Number of Pages
- 375 Pages
About this product
Product Information
Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called protein structural conformational diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book. Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the 2- 2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Straussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book. Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross- structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Product Identifiers
Publisher
Springer Verlag, Singapore
ISBN-13
9789811342479
eBay Product ID (ePID)
22046675205
Product Key Features
Publication Name
Molecular Dynamics Analyses of Prion Protein Structures: the Resistance to Prion Diseases Down under
Format
Paperback
Language
English
Subject
Chemistry
Publication Year
2018
Type
Textbook
Number of Pages
375 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
10
Item Weight
837g
Additional Product Features
Series Title
Focus on Structural Biology
Country/Region of Manufacture
Singapore
Item description from the seller
Business seller information
Value Added Tax Number:
- GB 976952259
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eBay item number:314643857516
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