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Naveen Patel Aparna L Enhancement of solubility of Mebendazole by S (Paperback)
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eBay item number:315066198822
Item specifics
- Condition
- Book Title
- Enhancement of solubility of Mebendazole by SEDDS
- Publication Name
- Enhancement of Solubility of Mebendazole by Sedds
- Title
- Enhancement of solubility of Mebendazole by SEDDS
- Format
- Trade Paperback
- ISBN-10
- 3659116335
- EAN
- 9783659116339
- ISBN
- 9783659116339
- Publisher
- LAP Gmbh & Company KG
- Genre
- Medicine
- Release Date
- 01/05/2012
- Release Year
- 2012
- Language
- English
- Country/Region of Manufacture
- DE
- Item Height
- 0.2in
- Item Length
- 9in
- Item Width
- 6in
- Item Weight
- 5.9 Oz
- Type
- Textbook
- Publication Year
- 2012
- Number of Pages
- 104 Pages
About this product
Product Information
The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness.
Product Identifiers
Publisher
LAP Gmbh & Company KG
ISBN-10
3659116335
ISBN-13
9783659116339
eBay Product ID (ePID)
144105998
Product Key Features
Publication Name
Enhancement of Solubility of Mebendazole by Sedds
Format
Trade Paperback
Language
English
Publication Year
2012
Type
Textbook
Number of Pages
104 Pages
Dimensions
Item Length
9in
Item Height
0.2in
Item Width
6in
Item Weight
5.9 Oz
Additional Product Features
Topic
Pharmacology
Genre
Medical
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eBay item number:315066198822
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