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Tachykinins by Peter Holzer (English) Paperback Book
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- Buy It NowTachykinins by Peter Holzer (English) Paperback Book
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eBay item number:386706786199
Item specifics
- Condition
- ISBN-13
- 9783642623424
- Book Title
- Tachykinins
- ISBN
- 9783642623424
- Subject Area
- Science, Medical
- Publication Name
- Tachykinins
- Item Length
- 9.3 in
- Publisher
- Springer Berlin / Heidelberg
- Subject
- Life Sciences / Neuroscience, Life Sciences / Human Anatomy & Physiology, Pharmacology
- Publication Year
- 2012
- Series
- Handbook of Experimental Pharmacology Ser.
- Type
- Textbook
- Format
- Trade Paperback
- Language
- English
- Item Width
- 6.1 in
- Item Weight
- 31.2 Oz
- Number of Pages
- Xii, 569 Pages
About this product
Product Information
More than 70 years have elapsed since U. S. von Euler and I. H. Gaddum dis- covered an unidentified depressor substance in the brain and gut. The effects of the powdery extracts were marked as 'P' on the kymograph tracings, and the nondescript name of 'substance P' still carries the breath of this adventurous period. In the 1960s, substance P returned in another disguise, staging as a hypothalamic peptide that causes copious salivary secretion (see chapter by F. Lembeck and I. Donnerer). This time, though, the mysterious substance was tracked down by S. E. Leeman and her collaborators as an undecapeptide, after it had eluded its identification for some 40 years. Substance P turned out to be the mammalian counterpart of a family of peptides which had been extracted from amphibian and nonvertebrate species and which had been given the name 'tachykinins' by V. Erspamer. Soon novel members of this peptide family were discovered, and in mammals substance P was joined by neurokinin A and neu- rokinin B. The presence of tachykinins in frog skin as well as in venoms and toxins of microbes and arachnids raises the possibility that these peptides re- present an old system of biological weapons that have been transformed to a particular messenger system in mammals.
Product Identifiers
Publisher
Springer Berlin / Heidelberg
ISBN-10
3642623425
ISBN-13
9783642623424
eBay Product ID (ePID)
202541998
Product Key Features
Publication Name
Tachykinins
Format
Trade Paperback
Language
English
Subject
Life Sciences / Neuroscience, Life Sciences / Human Anatomy & Physiology, Pharmacology
Publication Year
2012
Series
Handbook of Experimental Pharmacology Ser.
Type
Textbook
Subject Area
Science, Medical
Number of Pages
Xii, 569 Pages
Dimensions
Item Length
9.3 in
Item Width
6.1 in
Item Weight
31.2 Oz
Additional Product Features
Intended Audience
Scholarly & Professional
Series Volume Number
164
Number of Volumes
1 Vol.
Lc Classification Number
Rm300-666
Table of Content
History of a Pioneering Neuropeptide: Substance P.- The Tachykinin Peptide Family, with Particular Emphasis on Mammalian Tachykinins and Tachykinin Receptor Agonists.- The Histochemistry of Tachykinin Systems in the Brain.- The Nomenclature of Tachykinin Receptors.- The Mechanism and Function of Agonist-Induced Trafficking of Tachykinin Receptors.- Tachykinin NK1 Receptor Antagonists.- Tachykinin NK2 Receptor Antagonists.- Tachykinin NK3 Receptor Antagonists.- Combined Tachykinin NK1, NK2, and NK3 Receptor Antagonists.- Pre-protachykinin and Tachykinin Receptor Knockout Mice.- Therapeutic Potential of Tachykinin Receptor Antagonists in Depression and Anxiety Disorders.- The Role of Tachykinins and the Tachykinin NK1 Receptor in Nausea and Emesis.- Substance P (NK1 Receptor Antagonists-Analgesics or Not'.- Role of Tachykinins in Neurogenic Inflammation of the Skin and Other External Surfaces.- Role of Tachykinins in Obstructive Airway Disease.- Role of Tachykinins in the Gastrointestinal Tract.
Copyright Date
2004
Dewey Decimal
615/.1 S 612/.015756
Dewey Edition
22
Illustrated
Yes
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