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James R Hanson Chemistry and Medicines (Hardback) (UK IMPORT)
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eBay item number:395134304634
Item specifics
- Condition
- Book Title
- Chemistry and Medicines
- Publication Name
- Chemistry and Medicines : an Introductory Text
- Title
- Chemistry and Medicines
- Subtitle
- An Introductory Text
- Format
- Hardcover
- EAN
- 9780854046454
- ISBN
- 9780854046454
- Publisher
- Royal Society of Real Chemistry, T.H.E.
- Genre
- Science Nature & Math
- Topic
- Technology & Engineering
- Release Date
- 17/08/2006
- Release Year
- 2006
- Country/Region of Manufacture
- GB
- Item Height
- 0.6in
- Item Length
- 9.2in
- Item Weight
- 18 Oz
- Language
- English
- Publication Year
- 2006
- Type
- Textbook
- Item Width
- 6.1in
- Number of Pages
- 166 Pages
About this product
Product Information
Medicinal chemistry incorporates bio-organic chemistry, organic synthetic methods, physical organic chemistry and organic reaction mechanisms. These areas of chemistry are crucial to the design and synthesis of new drugs, both in academia and the pharmaceutical industry. Chemistry and Medicines: An Introductory Text provides a general introduction to this fascinating subject. The first chapters contain a brief historical introduction followed by a description of the chemical features involved in the adsorption, distribution, metabolism and excretion of a drug. The remaining chapters describe the chemistry underlying the design and synthesis of some of the key drugs used to combat some major diseases of the peripheral and central nervous system, infectious diseases and cancers. A glossary and suggestions for further reading complete this textbook. The book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry.
Product Identifiers
Publisher
Royal Society of Real Chemistry, T.H.E.
ISBN-10
0854046453
ISBN-13
9780854046454
eBay Product ID (ePID)
57042604
Product Key Features
Publication Name
Chemistry and Medicines : an Introductory Text
Format
Hardcover
Language
English
Publication Year
2006
Type
Textbook
Number of Pages
166 Pages
Dimensions
Item Length
9.2in
Item Height
0.6in
Item Width
6.1in
Item Weight
18 Oz
Additional Product Features
Lc Classification Number
Rs403.H36 2006
Reviews
Illustrates the drug development process through the thoughts of medicinal or organic synthesis chemists, and is a must read for all biochemists in the drug development sector. Destined for undergraduate chemists and biochemists, the book also offers general consultancy for post graduate and professional drug development research scientists.....each chapter includes a brief, developmental history and synthesis of the most popular drugs.Development and discovery of antiseptics such as Dettol, penicillins, ?-lactam antibiotics and AZT is most interesting. Cancer chemotherapy and the use of monoclonal antibodies are well covered in this introductory text. Then the big medical challenge: parasitic infections., A highly readable book which covers all of the main types of drugs.....history of drug discovery is excellent......an excellent introduction to all classes of drugs., Illustrates the drug development process through the thoughts of medicinal or organic synthesis chemists, and is a must read for all biochemists in the drug development sector. Destined for undergraduate chemists and biochemists, the book also offers general consultancy for post graduate and professional drug development research scientists.....each chapter includes a brief, developmental history and synthesis of the most popular drugs.Development and discovery of antiseptics such as Dettol, penicillins, ß-lactam antibiotics and AZT is most interesting. Cancer chemotherapy and the use of monoclonal antibodies are well covered in this introductory text. Then the big medical challenge: parasitic infections., There are some science books that when reviewed you would be happy to lend out to colleagues while there are others that remain jealously guarded in a drawer. This book falls into the latter category.The content is based upon short medicinal chemistry lecture courses which have been given to students on summer schools.......students know medicinal chemistry is important and what they really need is an easy to read reference text. This is that book and I'm willing to bet that they won't be lending it out either., Illustrates the drug development process through the thoughts of medicinal or organic synthesis chemists, and is a must read for all biochemists in the drug development sector. Destined for undergraduate chemists and biochemists, the book also offers general consultancy for post graduate and professional drug development research scientists.....each chapter includes a brief, developmental history and synthesis of the most popular drugs.Development and discovery of antiseptics such as Dettol, penicillins, x-lactam antibiotics and AZT is most interesting. Cancer chemotherapy and the use of monoclonal antibodies are well covered in this introductory text. Then the big medical challenge: parasitic infections., INTRODUCING A CAREER IN THE DRUG INDUSTRY Chemistry and medicines: an introductory text J R Hanson Cambridge, UK: Royal Society of Chemistry 2006 192pp ISBN 9780854046454 Reviewed by Michael Waring Medicinal chemistry comprises aspects of medicine, pharmacology and biochemistry but, above all, it involves chemistry if new drugs are to be discovered. It offers work for graduates who want to use their training to make a difference in the world. This book is aimed at presenting the basics and enthusing the young to take up the challenge of a career in the pharmaceutical industry. The author's experience of giving short lecture courses qualifies him well for the task, and he has gone a long way towards his aim. The organisation of the diverse subject-matter is impeccable. The book is a model of concise teaching where few words are wasted and topics are logically presented with a minimum of fuss. Here and there are interposed an anecdote or historical note to lighten the texture and illustrate the remarkable progress of the subject through happy (or unhappy) accident. At just 192 pages there is no room to present more than the fundamentals in pretty terse form, but the balance that is achieved between chemistry, biology and medicine is excellent. In places where the author goes into detail he chooses examples that lie at the heart of his subject and exemplify the approaches and methodology that are peculiar to medicinal chemistry. Sadly, while the science and layout are good, the book is marred by a large number of trivial typos and small errors that could have been put right. Some are consistent, such as the insertion of a comma before every mention of the word 'which', causing some sentences to read awkwardly or even distorting the meaning. Others are schoolboy howlers, like the formation of plagues (rather than plaques) in Alzheimer's disease. , Illustrates the drug development process through the thoughts of medicinal or organic synthesis chemists, and is a must read for all biochemists in the drug development sector. Destined for undergraduate chemists and biochemists, the book also offers general consultancy for post graduate and professional drug development research scientists.....each chapter includes a brief, developmental history and synthesis of the most popular drugs. Development and discovery of antiseptics such as Dettol, penicillins, ß-lactam antibiotics and AZT is most interesting. Cancer chemotherapy and the use of monoclonal antibodies are well covered in this introductory text. Then the big medical challenge: parasitic infections.
Table of Content
Chapter 1: Introduction; 1.1: Aims; 1.2: The Classification of Drugs; 1.3: Targets for the Medicinal Chemist; 1.4: The Stages in the Development of a Drug; 1.5: The Synthesis of a Drug; 1.6: The History of Medicinal Chemistry; Chapter 2: General Principles of Medicinal Chemistry; 2.1: Aims; 2.2: Administration and Absorption; 2.3: The Gastrointestinal Tract; 2.4: Other Routes of Administration; 2.5: Physico-Chemical Measurements; 2.6: Formulation; 2.7: Drug Metabolism; 2.8: Oxidation by Cytochrome P450s; 2.9: The Hydroxylation of Aromatic Rings; 2.10: The Hydroxylation of Aliphatic Systems; 2.11: The Monoamine Oxidases; 2.12: Other Phase One Changes; 2.13: Phase Two Changes; 2.14: Excretion; 2.15: Pro-Drugs; 2.16: Quantitative Structure: Activity Relationships; 2.17: Hansch QSAR Analyses; 2.18: Craig Plots and the Topliss Decision Tree; 2.19: Drug: Receptor Interactions; Chapter 3: Neurotransmitters as Targets; 3.1: Aims; 3.2: Introduction; 3.3: The Nervous System; 3.4: The Neurotransmitters; 3.5: Cell-Surface Receptors; 3.6: Ion-Channel-Linked Receptors; 3.7: Kinase-Linked Receptors; 3.8: G-Protein-Linked Receptors; 3.9: Agonists and Antagonists; 3.10: Acetylcholine; 3.11: Neuromuscular Blocking Agents in Surgery; 3.12: Muscarinic Agonists; 3.13: Local Anaesthetics; 3.14: Catecholamines as Neurotransmitters; 3.15: The Adrenergic Receptors; 3.16: a-Adrenergic Receptor Agonists; 3.17: b-Adrenergic Receptor Agonists - The Developmentof Anti-Asthma Drugs; 3.18: b1-Adrenergic Antagonists 'b-Blockers'; 3.19: The Treatment of Hypertension; Chapter 4 Medicinal Chemistry and the Central Nervous System; 4.1: Aims; 4.2: Introduction; 4.3: The Treatment of Neurodegenerative Diseases; 4.4: Dopamine Antagonists as Neuroleptic Agents; 4.5: Serotonin as a Neurotransmitter; 4.6: The Treatment of Depression; 4.7: GABA as a Neurotransmitter; 4.8: The Treatment of Epilepsy; 4.9: Benzodiazepines as Anxiolytic Agents; 4.10: Barbiturate Sleeping Tablets; 4.11: Opioids as Analgesics; Chapter 5: Local and Circulatory Hormone Targets; 5.1: Aims; 5.2: Introduction; 5.3: Histamine as a Target; 5.4: Histamine Antagonists in the Treatment of Peptic Ulcers; 5.5: The Prostaglandins and Non-Steroidal Anti-Inflammatory Agents; 5.6: The Development of Ibuprofen; 5.7: The Mechanism of Action of Aspirin; 5.8: Medicinal Uses of Prostaglandins; 5.9: The Sterols and Steroid Hormones; 5.10: The Biosynthesis of the Steroids; 5.11: The Control of Cholesterol Biosynthesis; 5.12: The Steroidal Anti-Inflammatory Agents; 5.13: The Steroidal Oral Contraceptives; 5.14: The Role of Nitric Oxide; Chapter 6: Anti-infective Agents; 6.1: Aims; 6.2: Introduction; 6.3: Bacterial Diseases; 6.4: Antiseptics; 6.5: The Sulfonamide Anti-Bacterial Agents; 6.6: The Penicillins; 6.7: Clavulanic Acid and the Inhibition of b-Lactamases; 6.8: The Cephalosporins; 6.9: The Mode of Action of the b-Lactam Antibiotics; 6.10: Other Antibiotics; 6.11: Synthetic Anti-Bacterial Agents; 6.12: Anti-Viral Agents; 6.13: The Inhibition of Nucleic Acid Biosynthesis; 6.14: Inhibitors of Reverse Transcriptase; 6.15: Neuraminidase Inhibitors; 6.16: The Synthesis of Nucleoside Analogues; 6.17: Anti-Fungal Agents; 6.18: Ergosterol Biosynthesis Inhibitors; 6.19: Other Anti-Fungal Agents; 6.20: Parasitic Infections; Chapter 7: Cancer Chemotherapy; 7.1: Aims; 7.2: Introduction; 7.3: The Cell Cycle; 7.4: Cancer Chemotherapy; 7.5: Anti-Metabolites; 7.6: Alkylating Agents; 7.7: Intercalating Agents; 7.8: Anti-Mitotic Agents; 7.9: Interference with Selected Developmental Processes; 7.10: Monoclonal Antibodies; 7.11: Prostate Cancer; Further Reading; Glossary; Subject Index
Copyright Date
2006
Topic
Food Science, Chemistry / Clinical, Biochemistry
Lccn
2006-491858
Dewey Decimal
615.19
Intended Audience
College Audience
Dewey Edition
22
Illustrated
Yes
Genre
Technology & Engineering, Science, Medical
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eBay item number:395134304634
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