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About this product
Product Identifiers
PublisherWiley & Sons, Incorporated, John
ISBN-103527310886
ISBN-139783527310883
eBay Product ID (ePID)51437385
Product Key Features
Number of Pages774 Pages
Publication NameBlood-Brain Barriers : from Ontogeny to Artificial Interfaces
LanguageEnglish
SubjectNeurology, Neuroscience
Publication Year2006
TypeTextbook
Subject AreaMedical
AuthorRolf Dermietzel
FormatHardcover
Dimensions
Item Height1.9 in
Item Weight62.6 Oz
Item Length9.7 in
Item Width7.3 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN2006-436629
Dewey Edition22
Reviews"...the authors have succeeded in making a great leap forward towards a better understanding of the structure and function of cerebral microvessels. Hopefully the book will find a broad readership and become a benchmark for blood-brain barrier textbooks." ChemMedChem
Number of Volumes2 vols.
IllustratedYes
Dewey Decimal612.824
Table Of ContentPreface.List of Contributors.VOLUME 1.Introduction.The Blood-Brain Barrier: An Integrated Concept (Rolf Dermietzel, David C. Spray, and Maiken Nedergaard).Part I Ontogeny of the Blood-Brain Barrier.1 Development of the Blood-Brain Interface (Britta Engelhardt).1.1 Introduction.1.2 Pioneering Research on the Blood-Brain Barrier.1.3 The Mature Blood-Brain Interface.1.4 Development of the CNS Vasculature.1.5 Differentiation of the Blood-Brain Barrier.1.6 Maintenance of the Blood-Brain Barrier.1.7 Outlook.2 Brain Angiogenesis and Barriergenesis (Jeong Ae Park, Yoon Kyung Choi, Sae-Won Kim,and Kyu-Won Kim).2.1 Introduction.2.2 Brain Angiogenesis.2.3 Oxygenation in the Brain: Brain Barriergenesis.2.4 Perspectives.3 Microvascular Influences on Progenitor Cell Mobilization and Fate in the Adult Brain (Christina Lilliehook and Steven A. Goldman).3.1 Introduction.3.2 Angiogenic Foci Persist in the Adult Brain.3.3 Neurotrophic Cytokines Can Be of Vascular Origin.3.4 Angiogenesis and Neurogenesis are Linked in the Adult Avian Brain.3.5 Angiogenesis-Neurogenesis Interactions in the Adult Mammalian Brain.3.6 Purinergic Signaling to Neural Progenitors Cells: the Gliovascular Unit as a Functional Entity.3.7 Nitric Oxide is a Local Modulator of Progenitor Cell Mobilization.3.8 Parenchymal Neural Progenitor Cells May Reside Among Microvascular Pericytes.3.9 The Role of the Vasculature in Post-Ischemic Mobilization of Progenitor Cells.Part II The Cells of the Blood-Brain Interface. 4 The Endothelial Frontier (Hartwig Wolburg).4.1 Introduction.4.2 The Brain Capillary Endothelial Cell.4.3 Endothelial Structures Regulating Transendothelial Permeability.4.4 Brief Consideration of the Neuroglio-Vascular Complex.4.5 Conclusions.5 Pericytes and Their Contribution to the Blood-Brain Barrier (Markus Ramsauer).5.1 Introduction.5.2 Pericyte Structure and Positioning.5.3 Pericyte Markers.5.4 Pericytes in Culture.5.5 Contractility and Regulation of Blood Flow.5.6 Macrophage Function.5.7 Regulation of Homeostasis and Integrity.5.8 Angiogenesis and Stability.5.9 Conclusion.6 Brain Macrophages: Enigmas and Conundrums (Frederic Mercier, Sebastien Mambie, and Glenn I. Hatton).6.1 Introduction.6.2 Different Types and Locations of Brain Macrophages.6.3 Migration of Brain Macrophages.6.4 Fast Renewal of Brain Macrophages.6.5 Functions.6.6 Conclusion: Macrophages as Architects of the CNS Throughout Adulthood.7 The Microglial Component (Ingo Bechmann, Angelika Rappert, Josef Priller, and Robert Nitsch).7.1 Microglia: Intrinsic Immune Sensor Cells of the CNS.7.2 Terminology: Subtypes and Their Location in Regard to Brain Vessels.7.3 Turnover of Brain Mononuclear Cells by Precursor Recruitment Across the BBB.7.4 Microglial Impact on BBB Functi
SynopsisThe Pimsleur(R) Method has worked for millions all over the world. Totally portable; simple to use; Pimsleur works so you don t have to. English for Brazilian Portuguese Speakers Phase 1, Unit 7 builds on material taught in prior units. It includes 30 minutes of spoken language practice, with an introductory conversation, new vocabulary, and new structures. Detailed instructions enable you to understand and participate in the conversation. The lesson contains full practice for all vocabulary introduced in this unit and in previous units. The emphasis is on pronunciation and comprehension, and on learning to "speak" English., Covering information dealing with the latest blood-brain interface research, this first handbook to combine the various structural and functional features involved in the regulation of brain perfusion and neuronal function highlights pharmacological and biomedical applications. ., This is the first handbook to integrate developmental and cellular aspects combining the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain. Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book is of interest to neurobiologists, neurologists, biochemists, and pharmacologists.
LC Classification NumberQP375.5
